Generic Name: s-adenosylmethionine (s ad in O si l met hi o nine)
Brand names: Natrol SAMe
What is s-adenosylmethionine?
S-adenosylmethionine is a naturally occurring chemical in the body.
S-adenosylmethionine has been used for depression, osteoarthritis, joint health and liver problems.
S-adenosylmethionine has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of s-adenosylmethionine may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
S-adenosylmethionine may also have uses other than those listed in this medication guide.
The use of s-adenosylmethionine in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal/health supplements, consultation with a primary health care professional is advisable. Additionally, consultation with a practitioner trained in the uses of herbal/health supplements may be beneficial, and coordination of treatment among all health care providers involved may be advantageous.
What is the most important information I should know about s-adenosylmethionine?
S-adenosylmethionine has not been evaluated by the FDA for safety, effectiveness, or purity. All potential risks and/or advantages of s-adenosylmethionine may not be known. Additionally, there are no regulated manufacturing standards in place for these compounds. There have been instances where herbal/health supplements have been sold which were contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.
Talk to your doctor before taking s-adenosylmethionine if you are taking anti-depressant medications. Do not stop or adjust your dose of anti-depressant medication without first talking to your doctor.
What should I discuss with my healthcare provider before taking s-adenosylmethionine?
Before taking s-adenosylmethionine, talk to your doctor, pharmacist, or health care professional if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements. S-adenosylmethionine may not be recommended in some situations.
Talk to your doctor before taking s-adenosylmethionine if you are taking anti-depressant medications. Do not stop or adjust your dose of anti-depressant medication without first talking to your doctor.
Do not take s-adenosylmethionine without first talking to your doctor if you are pregnant or could become pregnant. Do not take s-adenosylmethionine without first talking to your doctor if you are breast-feeding a baby. There is no information available regarding the use of s-adenosylmethionine by children. Do not give any herbal/health supplement to a child without first talking to the child's doctor.
How should I take s-adenosylmethionine?
If you choose to take s-adenosylmethionine, use it as directed on the package or as directed by your doctor, pharmacist, or other health care provider.
Do not use different formulations (e.g., tablets and powder) of s-adenosylmethionine at the same time, unless specifically directed to do so by a health care professional.
Store s-adenosylmethionine as directed on the package. In general, s-adenosylmethionine should be protected from light and moisture and stored in a sealed container.
What happens if I miss a dose?
No information is available regarding a missed dose of s-adenosylmethionine. Consult your doctor, pharmacist, or health care professional if you require further information.
What happens if I overdose?
Seek emergency medical attention if an overdose is suspected.
Symptoms of a s-adenosylmethionine overdose are not known.
What should I avoid while taking s-adenosylmethionine?
There are no known restrictions on food, beverages, or activity while taking s-adenosylmethionine, unless otherwise directed by your health care professional.
S-adenosylmethionine side effects
Stop taking s-adenosylmethionine and seek emergency medical attention if you experience symptoms of a serious allergic reaction including difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives.
Other less serious side effects of s-adenosylmethionine may include stomach ache, nausea, diarrhea, gas, anxiety, spasms and insomnia. Talk to your doctor, pharmacist, or health care professional if you experience any side effects from s-adenosylmethionine.
What other drugs will affect s-adenosylmethionine?
Interactions between s-adenosylmethionine and other prescription or over-the-counter medicines or herbal/health supplements have not been reported. Talk to your doctor, pharmacist, or health care professional before taking s-adenosylmethionine if you are taking any other medicines or supplements.
More s-adenosylmethionine resources
- S-adenosylmethionine Side Effects (in more detail)
- S-adenosylmethionine Use in Pregnancy & Breastfeeding
- S-adenosylmethionine Support Group
- 2 Reviews for S-adenosylmethionine - Add your own review/rating
- S-Adenosylmethionine MedFacts Consumer Leaflet (Wolters Kluwer)
Compare s-adenosylmethionine with other medications
- Osteoarthritis
Where can I get more information?
- Your doctor, pharmacist, or health care provider may have more information about s-adenosylmethionine.
See also: s-adenosylmethionine side effects (in more detail)
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